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Background Increasing evidence points to a role for the extra-neuronal nerve growth factor (NGF) in acquired immune responses. However, very little information is available about its role and underlying mechanism in innate immunity. Via Krishan Maggon
Gilbert C FAURE's insight:
Conclusions
To best of our knowledge, this is the first report shedding light on the mechanistic aspect of a neuroregulatory molecule, NGF, in innate immune response, and thus enriches our understanding regarding its pathogenic role in inflammation. These observations add further evidence in favor of anti-NGF therapy in autoimmune diseases and also unlock a new area of research about the role of NGF in IL-1β mediated diseases. 
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Citation: Datta-Mitra A, Kundu-Raychaudhuri S, Mitra A, Raychaudhuri SP (2015) Cross Talk between Neuroregulatory Molecule and Monocyte: Nerve Growth Factor Activates the Inflammasome. PLoS ONE 10(4): e0121626. doi:10.1371/journal.pone.0121626