Highlights•PTX3 deficiency unleashes Complement-dependent tumor-promoting inflammation•Tumors developed in a PTX3-deficient context have higher frequency of mutated Trp53•PTX3 expression is epigenetically repressed in selected human tumors•Complement is an essential component of tumor-promoting inflammation
Via Krishan Maggon
Cell Volume 160, Issue 4, p700–714, 12 February 2015