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Highlights•PTX3 deficiency unleashes Complement-dependent tumor-promoting inflammation•Tumors developed in a PTX3-deficient context have higher frequency of mutated Trp53•PTX3 expression is epigenetically repressed in selected human tumors•Complement is an essential component of tumor-promoting inflammation
Via Krishan Maggon
Cell Volume 160, Issue 4, p700–714, 12 February 2015
PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in CancerEduardo Bonavita, Stefania Gentile, Marcello Rubino, Virginia Maina, Roberto Papait, Paolo Kunderfranco, Carolina Greco,Francesca Feruglio, Martina Molgora, Ilaria Laface, Silvia Tartari, Andrea Doni, Fabio Pasqualini, Elisa Barbati, Gianluca Basso,Maria Rosaria Galdiero, Manuela Nebuloni, Massimo Roncalli, Piergiuseppe Colombo, Luigi Laghi, John D. Lambris, Sébastien Jaillon,Cecilia Garlanda, Alberto Mantovani DOI: http://dx.doi.org/10.1016/j.cell.2015.01.004