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J Immunol. 2014 Nov 7. pii: 1400859. [Epub ahead of print] 
Gilbert C FAURE's curator insight,
November 10, 2014 11:49 AM
Have a Functional Activation Advantage To Efficiently Kill Glioblastoma
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Genes and Immunity is a journal dedicated to functional genetics of the immune response. Emphasizing studies that demonstrate genetic, genomic or functional variation in the immune system, Genes and Immunity assists our understanding of how the basic control over the immune system varies between individuals both in health and disease.
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Abstract
Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms mediating their efficacy. We demonstrate that KIR2DS2 immunogenotype NK cells were more potent killers, notwithstanding the absence of inhibitory killer Ig-like receptor (KIR)-HLA ligand mismatch....