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Severely Depressed Interleukin-17 Production by Human Neonatal Mononuclear Cells @uutah http://t.co/vv4s21oIay 
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Scientists Develop Prototype Bactericidal Tuberculosis Vaccine that Elicits ...Genetic Engineering NewsA team at the Albert Einstein College of Medicine's Howard Hughes Medical Institute (HHMI) removed the bacterium's own esx-3 gene region, which...
Gilbert C FAURE's insight:
At the level of immune response, the demonstration that IKEPLUS immunization boosts IL-12 p40 and IFN-γ production suggested that enhanced TH1 cell responses were involved in the increased levels of protective immunity after Mtb challenge. Indeed, mice immunized with either IKE or IKEPLUS showed rapid induction of IL-12 p40 and IFN- γ expression within the first two days of high-dose intravenous challenge with Mtb. These data suggested that the protective responses elicited by IKEPLUS immunization were associated with the induction of TH1-type adaptive immunity, which was supported by the finding that Rag1−/− and IL-12 p40-deficient mice showed no significant change in their high susceptibility to Mtb challenge after immunization with IKEPLUS.
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New insights into IL-12-mediated tumor suppression Nature.com IL-12 was originally identified in 1989 as a natural killer (NK) cell-stimulatory factor with multiple biologic effects on peripheral blood lymphocytes.1 It is mainly produced by...
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Our results suggest that profound deficiency of IL-17 production associated with a marked decrease in Th17 cells likely contributes significantly to the increased susceptibility of human neonates to invasive bacterial and fungal infections.