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Upon infection or immunization, all jawed vertebrate species generate proteins called antibodies that bind and neutralize pathogens. Strong and long-lasting antibody responses in warm-blooded species such as mammals are produced in secondary lymphoid microstructures (SLMs) among which germinal...
In the absence of class switch recombination and germinal centers, the mechanisms through which B cells from teleost fish mount extrafollicular immunoglobulin M (IgM) memory responses remains mostly unexplored. In this report, we demonstrate that teleost IgM+ B cells respond to CD40L, a thymus-dependent activation signal, similarly to mammalian B2 cells. However, when stimulated with different types of antigens, fish IgM+ B cells only reach a general activation state in response to antigens cataloged as thymus-independent 1 (TI-1) in mammals, as established through both functional assays and RNA sequencing. Interestingly, fish IgM+ B cells remained completely unresponsive to TI-2 antigens, suggesting that the engagement of innate receptors provided by TI-1 antigens is required for the activation of teleost B cells. Finally, a synergy between CD40L and TI-1 antigens was also demonstrated, further supporting that there is no clear dichotomy between thymus-dependent and TI responses in teleost fish.
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HistoryThe International Society of Fish and Shellfish Immunology (ISFSI) was established in 2010 and the first meeting under this name will be held in Vigo (Spain) in 2013 (June 25-28).
The Effect of Stress On Atlantic Salmon's Congenital Immunity to IPN Science Daily (press release) Koestan Gadan has studied the consequences of stress on the innate immune defence system of the salmon and how it makes the fish more susceptible to...
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Host responses against invading pathogens are basic physiological reactions of all living organisms. Since appearance of the first eukaryotic cells a series of defence mechanisms have evolved in or...
The long-held paradigm that B cells cannot uptake nonspecific particulate Ags for the initiation of primary adaptive immunity has been challenged by the recent discovery that teleost B cells have potent phagocytic and microbicidal abilities.
Editorial Board [Fish & Shellfish Immunology] - Publication date: May 2013Source:Fish & Shellfish Immunolo... http://t.co/WCOFIOANRS
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![B Cells in Teleost Fish Act as Pivotal Initiating APCs in Priming Adaptive Immunity: An Evolutionary Perspective on the Origin of the B-1 Cell Subset and B7 Molecules [IMMUNOGENETICS] | Immunology | Scoop.it](https://img.scoop.it/0kC-b95Z4baJE9o0fGtLWDl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
