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J Immunol. 2014 Nov 7. pii: 1400859. [Epub ahead of print]
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November 10, 2014 11:49 AM
Have a Functional Activation Advantage To Efficiently Kill Glioblastoma
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Abstract
Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms mediating their efficacy. We demonstrate that KIR2DS2 immunogenotype NK cells were more potent killers, notwithstanding the absence of inhibitory killer Ig-like receptor (KIR)-HLA ligand mismatch....