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Scoop.it!
Antioxid Redox Signal. 2014 Apr 10;20(11):1770-88. doi: 10.1089/ars.2013.5673. Epub 2014 Mar 3. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review 
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Scoop.it!
From molecules to physiology (RT @GSSHealth: Vitamin D Modulates Paracrine Signaling to Control M.
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Scoop.it!
by Arun Chauhan, Yuyang Sun, Biswaranjan Pani, Fredice Quenumzangbe, Jyotika Sharma, Brij B. Singh, Bibhuti B. Mishra
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Heme oxygenase-1 (HO-1) is a potential therapeutic target in many diseases, especially those mediated by oxidative stress and inflammation. HO-1 expression appears to regulate the homeostatic activity and distribution of mononuclear phagocytes (MP) in lymphoid tissue under physiological conditions. It also regulates the ability of MP to modulate the inflammatory response to tissue injury.
RECENT ADVANCES:The induction of HO-1 within MP-particularly macrophages and dendritic cells-modulates the effector functions that they acquire after activation. These effector functions include cytokine production, surface receptor expression, maturation state, and polarization toward a pro- or anti-inflammatory phenotype. The importance of HO-1 in MP is emphasized by their expression of specific receptors that primarily function to ingest heme-containing substrate and deliver it to HO-1.