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Nature Reviews Immunology | doi:10.1038/nri.2016.48
Gilbert C FAURE's insight:
Online access to this article has been provided by the nature.com content sharing initiative.
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Epigenetic modifications of the immune system in health and disease Nature.com The epigenetic status of these cells is fine-tuned under physiological conditions; however, its disturbance often results in the development of immunological disorders,...
Gilbert C FAURE's insight:
Certain environmental factors influence the differentiation and function of immune cells through epigenetic alterations. For example, commensal microbiota-derived metabolites inhibit histone deacetylases to induce regulatory T cells, whereas some infectious agents induce DNA methylation, resulting in the development of cancer. These data imply that epigenetic regulation of host defense cells, which are usually the first to encounter external antigens, is implicated in disease development. Here, we highlight recent advances in our understanding of the molecular mechanisms by which the epigenetic status of immune and epithelial cells is controlled.
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