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PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:
Abstract
The humoral arm of the immune system provides robust protection against extracellular pathogens via the production of antibody molecules that neutralize or facilitate the destruction of microorganisms. However, the humoral immune system also provides a significant barrier to solid organ transplantation due to the antibody-mediated recognition of non-self proteins and carbohydrates expressed on transplanted organs. Historically, the presence of donor-specific antibodies (DSA) that recognize donor HLA molecules, incompatible ABO blood group antigens and other endothelial or xenogeneic antigens was considered a contraindication to transplantation. However, recent advances in antibody testing and immunosuppressive therapies have made it possible to cross certain antibody barriers successfully. In this article, we review our current understanding of antibody-mediated processes in solid organ transplantation and discuss the clinically available treatment options for preventing and treating antibody-mediated rejection.
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Hide-And-Seek: Altered HIV Can't Evade Immune SystemScience Daily (press release)"The altered HIV doesn't overwhelm the system and instead triggers the innate immune response to kick in, like it does with any first virus encounter," says Graham.
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Amazon.com: Innate Immunity of Plants, Animals and Humans (Nucleic Acids and Molecular Biology) (9783540739296): Holger Heine: Books (GET IT NOW!
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Investigators Identify CD8 T Cell Transcription Signature that Predicts ...Genetic Engineering NewsCD4 and CD8 T cells were positively selected from peripheral blood mononuclear cells (PBMCs) for whole-genome transcriptional analyses, and the...
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WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity http://t.co/LsoHtDXn #JEMTCB...
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Bone marrow vaccination: A novel approach to enhance antigen specific antitumor immunity (Bone marrow vaccination: A novel approach to enhance antigen specific antitumor immunity http://t.co/6oohcpjv...)...
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PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival. Circulation. 2011 Sep 13;124(11 Suppl):S3-9. Authors: Deuse T, Seifert M, Phillips N, ...
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Ruslan Medzhitov Elected to National Academy of Sciences for Work on Innate Immunity, Universities Now allows you to have the latest information of the best univesities of the world...
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The results indicate that tolerance takes place in lymphoid organs, and surprisingly, the T cells do not become anergic but instead have a Th2 phenotype. The tolerant Th2 cells displayed reduced motility after tolerogen ...
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Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the ...
Gilbert C FAURE's insight:
Summary of latest Aegean Conferences meeting - the 7th Innate Immunity ConferenceBrings together findings of international scientists with different advanced perspectivesDiscusses Evolution of the Innate Immune System, Host-pathogen interactions, and interactions with adaptive immunity..... in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.
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Ibalizumab Study Casts a Ray of Hope for HIV-Positive People With Extensive Drug Resistance, at The Body PRO, the HIV/AIDS resource for health care professionals.
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Amazon.com: Innate and Adaptive Immunity in the Tumor Microenvironment (The Tumor Microenvironment) eBook: Eitan Yefenof: Kindle Store (Innate and Adaptive Immunity in the Tumor Microenvironment (The Tumor Microenvironment): Cancer cells are conti...)...
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The current issue of Harvard Medicine features an essay by Dr. Joseph Murray reflecting on the first successful organ transplantation. Murray discusses how his service as an army surgeon during World War II helped ...
Gilbert C FAURE's curator insight,
November 17, 2014 8:50 AM
Joseph E. Murray ’43B, a professor of surgery emeritus at Harvard Medical School, was awarded the Nobel Prize in Physiology or Medicine in 1990. A more complete story of human organ transplantation can be found in his autobiography, Surgery of the Soul (Science History Publications/USA, 2001). Anthony L. Komaroff, with whom he collaborated on the book and this article, is the Simcox–Clifford–Higby Professor of Medicine at Harvard Medical School and editor–in–chief of Harvard Health Publications.
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XinhuaSeven scientists awarded Shaw Prize in Hong KongXinhua...
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YM BioSciences Announces Nimotuzumab Data to be Reported at 2011 ECCO-ESMO ...MarketWatch (press release)A poster presentation entitled "Pilot Study of Target Therapy With EGFR Antibody (Nimotuzumab) in Patients With Unresectable Head and Neck Cancer"...
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In the current issue of Journal of Steroids & Hormonal Science Innate Immunity in the Lower Female Mucosal Tract...
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T-DM1 is an antibody drug conjugate which contains chemotherapy (maytansine) stably linked to trastuzumab (Herceptin®) – this both inhibits HER2 signalling and delivers the chemotherapy directly inside HER2-positive ...
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Eculizumab Gains FDA ApprovalDrug Discovery & DevelopmentEculizumab is a monoclonal antibody that inhibits the production of the terminal complement components C5a and the membrane attack complex C5b-9 by binding to complement protein C5.
Gilbert C FAURE's insight:
Eculizumab is a monoclonal antibody that inhibits the production of the terminal complement components C5a and the membrane attack complex C5b-9 by binding to complement protein C5. Prevention of C5a formation and the terminal complement complex inhibits complement-mediated thrombotic microangiopathy in patients with aHUS.
Michael Craver 's curator insight,
June 17, 2021 8:16 PM
https://vaporwavepsychedelic.com
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STOCKHOLM (Reuters) - Women with an aggressive type of advanced breast cancer can live significantly longer without their disease getting worse if they are treated with an experimental armed antibody drug (Cancer study boosts hopes for Roche's armed...
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Amazon.com: Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity eBook: C.
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The Shaw Prize Foundation has awarded seven scientists the 2011 Shaw Prize for their pioneering work on gamma ray bursts, innate immunity, and modern geometry and physics.
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Type=chm Size=31.2MB Published=2010 Code: http://www./file/1984439834/B659_HBKT5.rar.
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{BioMed Central via BioPortfolio} IntroductionMany studies have shown that monocyte human leukocyte antigen-DR (mHLA-DR) expression may be a good predictor for...
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